Advancing Ultrasound Neuromodulation Together
Developing global standards for reproducible, safe neuromodulation research and therapies that benefit society.
Essential Guides for Practitioners & Researchers
Comprehensive resources for documenting transcranial ultrasonic stimulation procedures with transparency and reproducibility. Covers step-by-step implementation, best practices, technical considerations, and evidence-based safety parameters for protecting subjects during stimulation.
Safety is a central part of ITRUSST
Thermal Bioeffects
Ultrasound energy converts to heat through tissue absorption. While neuromodulation uses lower intensities than ablative HIFU, thermal damage risks remain and must be managed by limiting acoustic energy absorption.
Mechanical Bioeffects
TUS can induce acoustic cavitation, where vapor cavities form and violently collapse, causing tissue damage. This risk requires controlling peak negative pressure and overall acoustic energy.
International Standards and Regulatory Guidelines
No universal TUS safety standards exist, though diagnostic ultrasound guidelines are referenced. The FDA emphasizes individualized simulations, documented acoustic parameters, and supporting data (simulated, benchtop, in vivo) with physical justifications and "worst case" scenario analysis.
Advancing Transcranial Ultrasonic Stimulation
Safety & Standarization
Safety is a central part of the purpose and establishing evidence-based guidelines for safe and consistent application worldwide.
Open Collaboration & Knowledge Sharing
Creating an inclusive ecosystem where expertise flows freely across institutions and borders.
Clinical Translation & Innovation
Bridging laboratory discoveries with effective solutions for neurological challenges.
